Application Bibliography
| Application | Area Product | Reference | Date |
|---|---|---|---|
Fluorescence recovery after photobleaching (FRAP) reveals the role of HMGB1 in chromatin dynamics. | Confocal Microscopy CELESTA Light Engine | 2025 | |
Activation of lipolysis by breast cancer tumor cells in surrounding healthy tissues leads to increased tumorigenesis as imaged in primary human tissue and murine models. | Immunofluorescence Microscopy SPECTRA X Light Engine | Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis. Nat Commun (2025) 16(1):7438 J Williams, R Camarda, A Goga et al. | 2025 |
Sugar-sweetened beverage consumption causes increased colorectal cancer metastasis through elevation of cytosolic NAD+/NADH ratio. | Live Cell Microscopy SPECTRA X Light Engine | 2025 | |
Development of novel fluorescent potassium ion indicators for use in live cell and intravital imaging. | Microscopy Technique Development SPECTRA Light Engine | Sensitive red fluorescent indicators for real-time visualization of potassium ion dynamics in vivo. PLoS Biol (2025) 23(9):e3002993 L Yang, V Pathiranage, KD Piatkevich et al. | 2025 |
Determination of the role of Activin and BMP4 in stem cell fate during human gastrulation using live cell imaging and mathematical modeling. | Live Cell Microscopy SPECTRA X Light Engine | 2025 | |
The role of CENP-F and its regulation during mitosis using spinning disk confocal microscopy | Confocal Microscopy CELESTA Light Engine | 2025 | |
Using CRISPR-based optical pooled screening to discover the regulatory networks used during synaptogenesis | High-Content Screening CELESTA Light Engine | 2025 | |
Using a novel gut epithelial organoid model to determine the mechanism of Shigella infections in the human intenstinal epithelium | Live Cell Microscopy SPECTRA X Light Engine | A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen. Nat Genet (2025) ML Di Martino, L Jenniches, ME Sellin et al. | 2025 |
Development of a novel diagnostic instrument to provide rapid, in situ detection of the heart attack marker Creatine Kinase-MB | Diagnostics SOLA Light Engine | Microscope-Free Analyte Detection Based on Fiber-Optic Gliding Motility Assays. Small. (2025) e2411836 H Carey-Morgan, N Polley, S Diez et al. | 2025 |
Spinning disc confocal imaging of murine brain slices to detect synaptic protein turnover during learning | Confocal Microscopy SPECTRA X Light Engine | 2025 | |
Development of a multi-color microendoscope with single-cell resolution for intravital fluorescent imaging of rodent models | Intravital Imaging AURA Light Engine | Functional Microendoscopy Reveals Calcium Responses of Single Cells in Tracheal Tuft Cells and Kidney Podocytes. Small (2025) e2411341 TA Dancker, MI Elhawy, MA Lauterbach et al. | 2025 |
Intravital imaging of an epileptic mouse model hippocampus to detect ATP using FRET-based sensors | Intravital Imaging SPECTRA X Light Engine | Dynamics of Neuronal and Astrocytic Energy Molecules in Epilepsy. J Neurochem. (2025) 169(3):e70044 K Furukawa, Y Ikoma, K Matsui et al. | 2025 |
Live cell microscopy of chromatin dynamics during mitosis in human cell lines | Live Cell Microscopy SPECTRA X Light Engine | 2025 | |
Novel reversibly photoswitching fluorescent protein for use in superresolution imaging techniques | Microscopy Technique Development SPECTRA X Light Engine | 2025 | |
Live-cell imaging to determine cell cycle states and synchronization in human cell lines | Live Cell Microscopy SPECTRA X Light Engine | 2025 | |
Correlative FISH and fluorescent protein expression to analyze transcription factor kinetics in bacteria | Fluorescence in Situ Hybridization (FISH) SPECTRA Light Engine | Anti-correlation of LacI association and dissociation rates observed in living cells. Nat Commun. (2025) 16(1):764 V Kandavalli, S Zikrin, J Elf and D Jones | 2025 |
Confocal microscopy of a novel biosensor to detect STING activation | Confocal Microscopy CELESTA Light Engine | A novel biosensor for the spatiotemporal analysis of STING activation during innate immune responses to dsDNA. EMBO J. (2025) doi: 10.1038/s44318-025-00370-y S Smarduch, SD Moreno-Velasquez, SP Acebrón et al. | 2025 |
Fluorescent in vivo imaging to improve tumor margin assesment in oral cancer | Intravital Imaging SPECTRA X Light Engine | 2025 | |
Widefield 3D deconvolution microscopy of FUCCI (fluorescent, ubiquitination-based cell cycle indicator) in RPE-1 cells | Confocal Microscopy SPECTRA X Light Engine | 2025 | |
Quantitive imaging analysis of vascular-targeted therapeutic efficacy in co-cultured human derived endothelial cells and adjacently localized metastatic renal cell carcinoma spheroids | Diagnostics SPECTRA Light Engine | 2025 | |
395 nm ultraviolet photopolymerization of polyethyleneglycol diacrylate (PEGDA) | Bioengineering SPECTRA X Light Engine | 2024 | |
MERFISH profiling of epigenomic and chromatin conformation dynamics during human brain development | Transcriptomics CELESTA Light Engine | Temporally distinct 3D multi-omic dynamics in the developing human brain. Nature (2024) 635:481–489 MG Heffel, J Zhou, C Luo et al. | 2024 |
395 nm and 440 nm photoactivation of caged ivabradine (BHQ-IVA) | Optogenetics SPECTRA X Light Engine | 2024 | |
Quantitative imaging of extracellular vesicle (EV) uptake in primary human lung fibroblasts | High-Content Screening CELESTA Light Engine | 2024 | |
648 nm-induced photooxidation of polycyclic aromatic hydrocarbons (PAH) | Environmental Science SPECTRA X Light Engine | 2024 |