The emergence of whole-slide digital imaging systems has expedited pathology workflows and advanced the detection, classification, and prognosis of diseases. Computational image analysis tools have lessened the reliance on expert assessments for interpretation. Molecular labeling technologies now enable cell-by-cell analysis of gene expression analysis across large tissue sections. These advances have necessitated parallel improvements in the quantity and quality of microscope illumination. In particular, illumination uniformity and stability are essential in the process of assembling large panoramic images from multiple fields of view. Furthermore, higher brightness translates to decreased acquisition times for each field of view, increasing slide throughput. Consequently, many of the whole-slide digital imaging systems currently on the market are built around Lumencor Light Engines.