Application Bibliography
| Application | Area Product | Reference | Date |
|---|---|---|---|
Activation of lipolysis by breast cancer tumor cells in surrounding healthy tissues leads to increased tumorigenesis as imaged in primary human tissue and murine models. | Immunofluorescence Microscopy SPECTRA X Light Engine | Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis. Nat Commun (2025) 16(1):7438 J Williams, R Camarda, A Goga et al. | 2025 |
Sugar-sweetened beverage consumption causes increased colorectal cancer metastasis through elevation of cytosolic NAD+/NADH ratio. | Live Cell Microscopy SPECTRA X Light Engine | 2025 | |
Determination of the role of Activin and BMP4 in stem cell fate during human gastrulation using live cell imaging and mathematical modeling. | Live Cell Microscopy SPECTRA X Light Engine | 2025 | |
Using a novel gut epithelial organoid model to determine the mechanism of Shigella infections in the human intenstinal epithelium | Live Cell Microscopy SPECTRA X Light Engine | A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen. Nat Genet (2025) ML Di Martino, L Jenniches, ME Sellin et al. | 2025 |
Spinning disc confocal imaging of murine brain slices to detect synaptic protein turnover during learning | Confocal Microscopy SPECTRA X Light Engine | 2025 | |
Intravital imaging of an epileptic mouse model hippocampus to detect ATP using FRET-based sensors | Intravital Imaging SPECTRA X Light Engine | Dynamics of Neuronal and Astrocytic Energy Molecules in Epilepsy. J Neurochem. (2025) 169(3):e70044 K Furukawa, Y Ikoma, K Matsui et al. | 2025 |
Live cell microscopy of chromatin dynamics during mitosis in human cell lines | Live Cell Microscopy SPECTRA X Light Engine | 2025 | |
Novel reversibly photoswitching fluorescent protein for use in superresolution imaging techniques | Microscopy Technique Development SPECTRA X Light Engine | 2025 | |
Live-cell imaging to determine cell cycle states and synchronization in human cell lines | Live Cell Microscopy SPECTRA X Light Engine | 2025 | |
Fluorescent in vivo imaging to improve tumor margin assesment in oral cancer | Intravital Imaging SPECTRA X Light Engine | 2025 | |
Widefield 3D deconvolution microscopy of FUCCI (fluorescent, ubiquitination-based cell cycle indicator) in RPE-1 cells | Confocal Microscopy SPECTRA X Light Engine | 2025 | |
395 nm ultraviolet photopolymerization of polyethyleneglycol diacrylate (PEGDA) | Bioengineering SPECTRA X Light Engine | 2024 | |
395 nm and 440 nm photoactivation of caged ivabradine (BHQ-IVA) | Optogenetics SPECTRA X Light Engine | 2024 | |
648 nm-induced photooxidation of polycyclic aromatic hydrocarbons (PAH) | Environmental Science SPECTRA X Light Engine | 2024 | |
Patterned photoinduction of apoptosis using the blue light—sensitive split transcription factor LOVpep | Optogenetics SPECTRA X Light Engine | Image-guided optogenetic spatiotemporal tissue patterning using μPatternScope. Nat Commun (2024) 15:10469 S Kumar, HM Beyer, M Khammash et al. | 2024 |
Time-lapse imaging of human umbilical vein endothelial cells (HUVECs) for spatiotemporal image correlation spectroscopy (STICS) analysis | Live Cell Microscopy SPECTRA X Light Engine | 2024 | |
Validation of aiSEGcell protocol applied to time-lapse imaging of NF-kappa B signaling dynamics | High-Content Screening SPECTRA X Light Engine | aiSEGcell: User-friendly deep learning-based segmentation of nuclei in transmitted light images. PLoS Comput Biol (2024) 20:e1012361 D Schirmacher, U Armagan, T Schroeder et al. | 2024 |
Freestanding bilayer microscopy (FBM) of human mechanosensitive potassium channel (hTRAAK) in lipid bilayer membranes | Biophysics SPECTRA X Light Engine | Freestanding bilayer microscope for single-molecule imaging of membrane proteins. Sci Adv (2024) 10:eado4722 G Pérez-Mitta, Y Sezgin, R MacKinnon et al., | 2024 |
Iterative indirect immunofluorescence imaging (4i) of retinoblastoma (Rb) phosphorylation in MCF-10A human mammary epithelial cells | Immunofluorescence Microscopy SPECTRA X Light Engine | An intermediate Rb–E2F activity state safeguards proliferation commitment. Nature (2024) 631:424–431 Y Konagaya, D Rosenthal, T Meyer et al. | 2024 |
Optical control of protein dimerization via reversible photoisomerization of an azobenzene ligand | Optogenetics SPECTRA X Light Engine | 2024 | |
Imaging T-cell calcium signaling elicited by a biomimetic antigen-presenting system (bAPS) | Bioengineering SPECTRA X Light Engine | 2024 | |
In situ sequencing (ISS) for single-cell spatial expression profiling of the spatiotemporal cellular dynamics underlying autoimmune encephalomyelitis (EAE) evolution. | Transcriptomics SPECTRA X Light Engine | Cellular architecture of evolving neuroinflammatory lesions P Kukanja, CM Langseth, G Castelo-Branco et al. | 2024 |
Imaging intracellular neuropeptide concentrations using a genetically encoded sensor comprising vasoactive intestinal peptide receptor VPAC1 coupled to circularly permuted GFP | Pathology SPECTRA X Light Engine | Multisensory gamma stimulation promotes glymphatic clearance of amyloid. Nature (2024) 627:149–156 MH Murdock, CY Yang, LH Tsai et al. | 2024 |
Simultaneous 473 nm photstimulation of ChR2 and 585 nm excitation of genetically encoded voltage indicator Voltron fluorescence in murine acute brain slices. | Optogenetics SPECTRA X Light Engine | Voltage-Seq: all-optical postsynaptic connectome-guided single-cell transcriptomics. Nat Methods (2023) 10:1409-1416 V Csillag, MH Bizzozzero, J Fuzik et al. | 2023 |
1) Photoactivation of ChR2 (467–499 nm) and ACR1 (500–550 nm) in C. elegans. (2) Excitation of genetically encoded fluorescent calcium indicators and jRGECO1a and GCaMP. | Optogenetics SPECTRA X Light Engine | Neural engineering with photons as synaptic transmitters. Nat Methods M Porta-de-la-Riva, AC Gonzalez, M Krieg et al. | 2023 |