Super-resolution imaging of RNA transcripts using multiplex error robust fluorescence in situ hybridization (MERFISH) and related methods in combination with the CELESTA Light Engine [1] requires higher levels of irradiance (mW/mm2) than can be obtained from Koehler illumination. To facilitate these applications, Lumencor has developed a series of epi-lluminators that provide uniform illumination over a smaller field of view but with much higher irradiance than typical Koehler illumination can provide. Epi- illuminators compatible with all major research microscope brands are available.