Optogenetics is the combination of genetic and optical methods to control specific events in targeted cells of living tissue in the millisecond timescale. Light is used to activate transgenically introduced photosensitive ion channels and enzymes, initiating bioelectrical and biochemical events whose progression is monitored by imaging or electrophysiological recording. Cost-competitive light engines now offer an alternative to laser arrays for optogenetics studies in live tissue sections and freely moving animals. Lumencor light engines provide the temporal precision needed to keep pace with functioning, intact, living biological systems; the ease of use of a pre-aligned multicolor output; and the safety and price advantages of a non-laser based illuminator. Published applications of Lumencor light engines for optogenetics are listed in our applications bibliography.